Determination of control coefficients in intact metabolic systems

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چکیده

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Determination of control coefficients in intact metabolic systems.

The control structure of a metabolic system can in principle be determined without the need for purification of the component enzymes and study of their kinetic properties, provided that their activities can be perturbed by amounts sufficient to produce measurable changes in the steady-state variables, i.e. the fluxes through the system and the concentrations of the intermediates. Each perturba...

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In the past two decades, several theories, all ultimately based upon the same power-law formalism, have been proposed to relate the behavior of intact biochemical systems to the properties of their underlying determinants. Confusion concerning the relatedness of these alternatives has become acute because the implications of these theories have never been compared. In the preceding paper we cha...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 1994

ISSN: 0264-6021,1470-8728

DOI: 10.1042/bj2980367